Background: Coronary angiography (CAG) is widely used to assess lumen dimensions, and optical coherence\ntomography (OCT) is used to evaluate the characteristics of atherosclerotic plaque. This study was aimed to\ncompare coronary lumen dimensions using CAG and plaque characteristics using OCT and their changes during\nstatin therapy.\nMethods: We identified 97 lipid-rich plaques from 69 statin-na�¯ve patients, who received statin therapy in the\nfollowing 12 months. CAG and OCT examinations were conducted at baseline and 12-month follow-up period.\nResults: Lesion length, as measured by CAG, was closely correlated with lipid length by OCT (baseline: r = 0.754,\np < 0.001; follow-up: r = 0.639, p < 0.001). However, no significant correlations were found between the other\nfindings on OCT and data on CAG. With 12-month statin therapy, microstructures of lipid-rich plaques were\nsignificantly improved, but CAG-derived lumen dimensions were not improved. Moreover, we found no significant\nrelationship between changes in OCT measurements and changes in CAG data over time.\nConclusion: Lipid length on OCT and lesion length on CAG were closely correlated. However, plaque\nmicrostructural characteristics on OCT showed no significantly statistically correlations with lumen dimensions on\nCAG, neither did their evolutionary changes induced by statin over time.
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